Athletic Bilbao kick off the action on Friday night against Las Palmas, however it is the race for the title that is on everyone’s minds.
Real Madrid travel to Sporting Gijon off the back of a fantastic Champions League victory in Munich, with Ronaldo and Co hoping to extend their lead at the top to six points.
However, with Barcelona in action just a matter of hours later, Luis Enrique’s side will be looking to take advantage of any slip-ups, as they host Real Sociedad at the Camp Nou.
Elsewhere, the battle for the final automatic Champions League place continues this weekend, with Atletico Madrid taking on the all-but relegated Osasuna, while a Sevilla side struggling for consistency face Valencia at the Mestalla.
La Liga Recommended Bets
Atletico Madrid to win against Osasuna @ 2/11 @Bet365)
Sporting Gijon to draw with Real Madrid @ 4/1 (Betway)